What type of social network is associated with greater well-being? We argue that the effects of social networks on well-being depend on individuals' self-regulatory orientation — a basic motivational factor. We propose that brokerage networks fit a promotion-focused orientation that is concerned with eagerly pursuing gains, whereas closure networks fit a prevention-focused orientation that is concerned with vigilantly maintaining non-losses. Therefore, brokerage networks have a positive effect on well-being among promotion-focused people, whereas closure networks have a positive effect on well-being among prevention-focused people. We find support for these hypotheses in an analysis of 379 managers who reported higher levels of well-being when their professional networks fit their regulatory orientations.